Ontology highlight
ABSTRACT:
SUBMITTER: Duhail T
PROVIDER: S-EPMC8453633 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Duhail Thibaut T Bortolato Tommaso T Mateos Javier J Anselmi Elsa E Jelier Benson B Togni Antonio A Magnier Emmanuel E Dagousset Guillaume G Dell'Amico Luca L
Organic letters 20210901 18
The first light-driven method for the α-trifluoromethoxylation of ketones is reported. Enol carbonates react with <i>N</i>-trifluoromethoxy-4-cyano-pyridinium, using the photoredox catalyst 4-CzIPN under 456 nm irradiation, affording the α-trifluoromethoxy ketones in ≤50% isolated yield and complete chemoselectivity. As shown by 29 examples, the reaction is general and proceeds very rapidly under batch (1 h) and flow conditions (2 min). Diverse product manipulations demonstrate the synthetic pot ...[more]