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Indium Tribromide-Catalysed Transfer-Hydrogenation: Expanding the Scope of the Hydrogenation and of the Regiodivergent DH or HD Addition to Alkenes.

ABSTRACT: The transfer-hydrogenation as well as the regioselective and regiodivergent addition of H-D from regiospecific deuterated dihydroaromatic compounds to a variety of 1,1-di- and trisubstituted alkenes was realised with InBr₃ in dichloro(m)ethane. In comparison with the previously reported BF₃ ⋅Et₂ O-catalysed process, electron-deficient aryl-substituents can be applied reliably and thereby several restrictions could be lifted, and new types of substrates could be transformed successfully in hydrodeuterogenation as well as deuterohydrogenation transfer-hydrogenation reactions.

SUBMITTER: Li L

PROVIDER: S-EPMC8453857 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Indium Tribromide-Catalysed Transfer-Hydrogenation: Expanding the Scope of the Hydrogenation and of the Regiodivergent DH or HD Addition to Alkenes.

Li Luomo L Hilt Gerhard G

Chemistry (Weinheim an der Bergstrasse, Germany) 20210621 43

The transfer-hydrogenation as well as the regioselective and regiodivergent addition of H-D from regiospecific deuterated dihydroaromatic compounds to a variety of 1,1-di- and trisubstituted alkenes was realised with InBr3 in dichloro(m)ethane. In comparison with the previously reported BF3 ⋅Et2 O-catalysed process, electron-deficient aryl-substituents can be applied reliably and thereby several restrictions could be lifted, and new types of substrates could be t ...[more]

PMID: 34048092

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