Dynamic cardiac PET motion correction using 3D normalized gradient fields in patients and phantom simulations.

ABSTRACT: This work expands on the implementation of three-dimensional (3D) normalized gradient fields to correct for whole-body motion and cardiac creep in [N-13]-ammonia patient studies and evaluates its accuracy using a dynamic phantom simulation model.

Methods

A full rigid-body algorithm was developed using 3D normalized gradient fields including a multi-resolution step and sampling off the voxel grid to reduce interpolation artifacts. Optimization was performed using a weighted similarity metric that accounts for opposing gradients between images of blood pool and perfused tissue without the need for segmentation. Forty-three retrospective dynamic [N-13]-ammonia PET/CT rest/adenosine-stress patient studies were motion corrected and the mean motion parameters plotted at each frame time po

SUBMITTER: Nye JA 

PROVIDER: S-EPMC8455441 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature