Ontology highlight
ABSTRACT:
SUBMITTER: Qi H
PROVIDER: S-EPMC8456208 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Qi Haozhe H Schmöhl Felix F Li Xiaogang X Qian Xin X Tabler Christoph T CT Bennewitz Katrin K Sticht Carsten C Morgenstern Jakob J Fleming Thomas T Volk Nadine N Hausser Ingrid I Heidenreich Elena E Hell Rüdiger R Nawroth Peter Paul PP Kroll Jens J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210718 18
Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications. However, the molecular mechanisms are mostly unknown, and a suitable animal model with internal increased ACR does not exist for in vivo studying so far. Several enzyme systems are responsible for acrolein detoxification, such as Aldehyde Dehydrogenase (ALDH), Aldo-Keto Reductase (AKR), and Glutathione S-Transferase (GST). To evaluate the function of ACR in glucose hom ...[more]