NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis.

ABSTRACT:

Objective

NFκB is the key modulator in inflammatory disorders. However, the key regulators that activate, fine-tune or shut off NFκB activity in inflammatory conditions are poorly understood. In this study, we aim to investigate the roles that NFκB-specific long non-coding RNAs (lncRNAs) play in regulating inflammatory networks.

Design

Using the first genetic-screen to identify NFκB-specific lncRNAs, we performed RNA-seq from the p65^-/- and Ikkβ^-/- mouse embryonic fibroblasts and report the identification of an evolutionary conserved lncRNA designated mNAIL (mice) or hNAIL (human). hNAIL is upregulated in human inflammatory disorders, including UC. We generated mNAIL^ΔNFκB mice, wherein deletion of two

SUBMITTER: Akıncılar SC 

PROVIDER: S-EPMC8458091 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature