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Fractional CO₂ laser to improve noticeable scars after skin cancer surgery: An appraisal by the patients, laypersons, and experts.

ABSTRACT: Ablative fractionated carbon dioxide (fCO₂ ) laser may be a useful tool to improve noticeable scars after skin cancer surgery. Therefore we evaluated 40 patients who have been treated with fCO₂ laser for facial scars after skin cancer surgery. This retrospective study is based on blinded evaluation of pre- and postoperative photographs. Patients (n = 40), laypersons (n = 5) and experts (n = 5) evaluated the esthetics and the Vancouver scar scale as primary endpoints. Secondary endpoints included patient satisfaction and treatment safety. Patients, laypersons and experts consistently assessed a significant improvement of scar quality and appearance after fCO₂ laser treatment, which was paralleled by high patient satisfaction. In conclusion, ablative fCO₂ laser is effective in improving noticeable postsurgical scars. Patients are highly satisfied with post-laser results.

SUBMITTER: Wyss N

PROVIDER: S-EPMC8459294 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Fractional CO2 laser to improve noticeable scars after skin cancer surgery: An appraisal by the patients, laypersons, and experts.

Wyss Nina N Graf Nicole N Hafner Juerg J Imhof Laurence L

Dermatologic therapy 20210531 4

Ablative fractionated carbon dioxide (fCO2 ) laser may be a useful tool to improve noticeable scars after skin cancer surgery. Therefore we evaluated 40 patients who have been treated with fCO2 laser for facial scars after skin cancer surgery. This retrospective study is based on blinded evaluation of pre- and postoperative photographs. Patients (n = 40), laypersons (n = 5) and experts (n = 5) evaluated the esthetics and the Vancouver scar scale as primary endpoints. Second ...[more]

PMID: 34022110

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Project description:BackgroundThe efficacy of adipose-derived mesenchymal stem cells (ADMSCs) secretome for skin aging has been established, yet no studies hitherto directly investigated the best administration method for such purpose.PurposeWe aimed to compare microneedling (MN) versus fractional CO2 laser (FL) as methods of delivery for ADMSCs secretome in the treatment of aging skin.Patients and methodsA single-blind, randomized split-face clinical trial was conducted on 30 Indonesian women (aged 35-59 years old) with signs of facial cutaneous senescence. Their initial aging status was assessed by dermoscopy photoaging scale (DPAS) and Janus-III measurement system. In the second and fourth weeks, all participants were treated with both MN and FL, followed by the application of a four-fold concentrated ADMSC secretome. The assignment of which side of the face received MN or FL was done by computer-based randomization. Skin parameters were reevaluated on the fourth and sixth weeks, along with patient satisfaction, level of comfort, preference for administration techniques, and also adverse events experienced during the study. Appropriate statistical analyses were subsequently performed at a significance level of 0.05.ResultsSignificant improvements in total DPAS and wrinkles were found in the MN and FL groups at the end of the trial. In contrast, no statistical differences in all parameters were observed between groups in the fourth and sixth weeks. FL scored higher than MN for satisfaction and preference, but lower in terms of comfort. Pain, burning sensation, and itch were the side effects experienced by subjects upon treatment. Two patients had prolonged reddish skin succeeding FL treatment, which relieved with moisturizer application.ConclusionBoth MN and FL yielded comparable results for improving several skin aging features. However, subjective preference for ADMSCs secretome administration method may differ when considering satisfaction, comfort, and possible adverse events.

Dataset Information

Fractional CO₂ laser to improve noticeable scars after skin cancer surgery: An appraisal by the patients, laypersons, and experts.

Publications

Fractional CO<sub>2</sub> laser to improve noticeable scars after skin cancer surgery: An appraisal by the patients, laypersons, and experts.

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