Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants.

ABSTRACT: Marine-derived fungi constitute an interesting source of bioactive compounds, several of which exhibit antibacterial activity. These acquire special importance, considering that antimicrobial resistance is becoming more widespread. The overexpression of efflux pumps, capable of expelling antimicrobials out of bacterial cells, is one of the most worrisome mechanisms. There has been an ongoing effort to find not only new antimicrobials, but also compounds that can block resistance mechanisms which can be used in combination with approved antimicrobial drugs. In this work, a library of nineteen marine natural products, isolated from marine-derived fungi of the genera Neosartorya and Aspergillus, was evaluated for their potential as bacterial efflux pump inhibitors as well as the

SUBMITTER: Duraes F 

PROVIDER: S-EPMC8470461 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature