Association Between Impaired Myocardial Flow Reserve on ⁸²Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease.

ABSTRACT:

Background

Coronary microvascular dysfunction has been described in patients with autoimmune rheumatic disease (ARD). However, it is unknown whether positron emission tomography (PET)-derived myocardial flow reserve (MFR) can predict adverse events in this population.

Methods

Patients with ARD without coronary artery disease who underwent dynamic rest-stress ⁸²Rubidium PET were retrospectively studied and compared with patients without ARD matched for age, sex, and comorbidities. The association between MFR and a composite end point of mortality or myocardial infarction or heart failure admission was evaluated with time to event and Cox-regression analyses.

Results

In 101 patients with ARD (88% female, age: 62±10 years), when compared with matched patients

SUBMITTER: Feher A 

PROVIDER: S-EPMC8475774 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature