A molecular taxonomy of tumors independent of tissue-of-origin.
Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen PT
PROVIDER: S-EPMC8477189 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
A molecular taxonomy of tumors independent of tissue-of-origin.
Nguyen Peter T PT Coetzee Simon G SG Lakeland Daniel L DL Hazelett Dennis J DJ
iScience 20210903 10
Cancer is an organism-level disease, impacting processes from cellular metabolism and the microenvironment to systemic immune response. Nevertheless, efforts to distinguish overarching mutational processes from interactions with the cell of origin for a tumor have seen limited success, presenting a barrier to individualized medicine. Here we present a pathway-centric approach, extracting somatic mutational profiles within and between tissues, largely orthogonal to cell of origin, mutational burd ...[more]
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