Hyperlipidemia Influences the Accuracy of Glucometer-Measured Blood Glucose Concentrations in Genetically Diverse Mice.

ABSTRACT:

Background

Glucometers are widely used in animal research due to simplicity and ease of utilization, but their accuracy in blood glucose assessment for hyperlipidemic mice is unknown.

Methods

Here, we compared blood glucose levels measured by a glucometer with plasma glucose levels measured by a standard enzymatic assay for 325 genetically diverse F2 mice derived from LP and BALB/c (BALB) Apoe^-/- mice. Non-fasting glucose levels were measured before initiation of a Western diet and after 11 weeks on the diet.

Results

On chow diet, lab-measured plasma glucose levels were 279.5 ± 42.6 mg/dl (mean ± SD), while blood glucose values measured by glucometer were 138.7 ± 16.6 mg/dl. The two measures had no correlation (R² = 0.006, p = 0.167). On the West

SUBMITTER: Shi LJ 

PROVIDER: S-EPMC8478864 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature