Maintaining serum ionized calcium during brisk walking attenuates the increase in bone resorption in older adults.

ABSTRACT:

Background

Endurance exercise can cause a decrease in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and bone resorption, reflected by serum carboxy-terminal collagen crosslinks (CTX). We developed a calcium clamp to prevent the decrease in iCa during exercise, which attenuated increases in PTH and CTX during vigorous cycling in young men. The goal was to determine whether this occurs in older adults during brisk walking.

Methods

Twelve older adults (6 men, 6 women) performed two identical 60-min treadmill walking bouts with Ca gluconate or half-normal saline infusion. Blood sampling for iCa, total calcium (tCa), phosphate (P), PTH, and CTX, occurred before, during, and for 4 h after exercise.

Results

iCa decreased during exercise with the sali

SUBMITTER: Wherry SJ 

PROVIDER: S-EPMC8478867 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature