Distinct toll-like receptor signaling in the salamander response to tissue damage.

ABSTRACT:

Background

Efficient wound healing or pathogen clearance both rely on balanced inflammatory responses. Inflammation is essential for effective innate immune-cell recruitment; however, excessive inflammation will result in local tissue destruction, pathogen egress, and ineffective pathogen clearance. Sterile and nonsterile inflammation operate with competing functional priorities but share common receptors and overlapping signal transduction pathways. In regenerative organisms such as the salamander, whole limbs can be replaced after amputation while exposed to a nonsterile environment. In mammals, exposure to sterile-injury Damage Associated Molecular Patterns (DAMPS) alters innate immune-cell responsiveness to secondary Pathogen Associated Molecular Pattern (PAMP) exposure.

Res

SUBMITTER: Debuque RJ 

PROVIDER: S-EPMC8484370 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature