Intrathymic differentiation of natural antibody-producing plasma cells in human neonates.

ABSTRACT: The thymus is a central lymphoid organ primarily responsible for the development of T cells. A small proportion of B cells, however, also reside in the thymus to assist negative selection of self-reactive T cells. Here we show that the thymus of human neonates contains a consistent contingent of CD138⁺ plasma cells, producing all classes and subclasses of immunoglobulins with the exception of IgD. These antibody-secreting cells are part of a larger subset of B cells that share the expression of signature genes defining mouse B1 cells, yet lack the expression of complement receptors CD21 and CD35. Data from single-cell transcriptomic, clonal correspondence and in vitro differentiation assays support the notion of intrathymic CD138⁺ plasma cell differentiation, alongsid

SUBMITTER: Cordero H 

PROVIDER: S-EPMC8486820 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature