Ontology highlight
ABSTRACT:
SUBMITTER: Borghesan E
PROVIDER: S-EPMC8488576 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Borghesan Elizabeth E Smith Erin P EP Myeni Sebenzile S Binder Kelsey K Knodler Leigh A LA Celli Jean J
The EMBO journal 20210823 19
Remodeling of host cellular membrane transport pathways is a common pathogenic trait of many intracellular microbes that is essential to their intravacuolar life cycle and proliferation. The bacterium Brucella abortus generates a host endoplasmic reticulum-derived vacuole (rBCV) that supports its intracellular growth, via VirB Type IV secretion system-mediated delivery of effector proteins, whose functions and mode of action are mostly unknown. Here, we show that the effector BspF specifically p ...[more]