The relationship between cannabis and schizophrenia: a genetically informed perspective.

ABSTRACT:

Background and aims

While epidemiological studies support a role for heavy, high-potency cannabis use on first-episode psychosis, genetic models of causation suggest reverse causal effects of schizophrenia on cannabis use liability. We estimated the genetic relationship between cannabis use disorder (CUD) and schizophrenia (SCZ) and tested whether liability for CUD is causally associated with increased liability to SCZ while adjusting for tobacco smoking.

Design

This study used summary statistics from published genome-wide association studies (GWAS). We used genomic structural equation modeling, latent causal variable analysis, and multivariable Mendelian randomization to examine genetic relationships between CUD, cannabis ever-use, ever-smoked tobacco regularly, nicotine de

SUBMITTER: Johnson EC 

PROVIDER: S-EPMC8492483 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature