Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya.

ABSTRACT:

Background

Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control.

Methods

In a 3-year case-control study, we investigated typhoid among children aged <16 years (4670 febrile cases and 8549 age matched controls) living in an informal settlement, Nairobi, Kenya.

Results

148 S. Typhi isolates from cases and 95 from controls (stool culture) were identified; a carriage frequency of 1 %. Whole-genome sequencing showed 97% of cases and 88% of controls were genotype 4.3.1 (Haplotype 58), with the majority of each (76% and 88%) being multidrug-resistant strains in three sublineages of the H58 genotype (East Africa 1 (EA1), EA2, and EA3), with sequences from cases and carriers interm

SUBMITTER: Kariuki S 

PROVIDER: S-EPMC8494480 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature