Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL).
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ABSTRACT: Background
Analysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) is a multi-site, multinational, observational cohort registry designed to collect data on the use of the magnetic resonance linear accelerator (MR-Linac) for radiation therapy and patient outcomes. The registry will provide a linked repository of technical and clinical data that will form a platform for prospective studies and technology assessment.Methods
Design: This registry aims to include an estimated 10,000 eligible participants across Australia and other countries over a 7- to 10-year period. Participants will undergo treatment and assessments in accordance with standard practice. Toxicity and survival outcomes will be assessed at baseline, during treatment, and with 3 monthly follow-up until 24 months, patient reported outcome measures will also be collected. Participants with a variety of cancers will be included.Discussion
Data obtained from the ADAPT-MRL registry is expected to provide evidence on the safety and efficacy of the MR-Linac, a new technical innovation in radiation oncology. We expect this registry will generate data that will be used to optimise treatment techniques, MR-Linac software algorithms, evaluate participants' outcomes and toxicities and to create a repository of adapted plans, anatomical and functional MR sequences linked to participants' outcomes.
SUBMITTER: de Leon J
PROVIDER: S-EPMC8495756 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Analysis of data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL).
de Leon Jeremiah J Woods Amanda A Twentyman Tania T Meade Michael M Sproule Vicki V Chandran Smitha S Christiansen Joseph J Kennedy Neil N Marney Maria M Barooshian Kris K Plit Michael M Lynch Jayd J Jagavkar Raj R Ormandy Helen H Christodouleas John J Pietzsch Florian F Chan Michael M Jameson Michael G MG
Clinical and translational radiation oncology 20210920
<h4>Background</h4>Analysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) is a multi-site, multinational, observational cohort registry designed to collect data on the use of the magnetic resonance linear accelerator (MR-Linac) for radiation therapy and patient outcomes. The registry will provide a linked repository of technical and clinical data that will form a platform for prospective studies and technology assessment.<h4>Methods</h4>Design: This registry aims to include a ...[more]
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