Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature myeloid cells with immunosuppressive effects, which undergo massive expansion during tumor progression. These cells not only support immune escape directly but also promote tumor invasion via various non-immunological activities. Besides, this group of cells are proved to impair the efficiency of current antitumor strategies such as chemotherapy, radiotherapy, and immunotherapy. Therefore, MDSCs are considered as potential therapeutic targets for cancer therapy. Treatment strategies targeting MDSCs have shown promising outcomes in both preclinical studies and clinical trials when administrated alone, or in combination with other anticancer therapies. In this review, we shed new light on recent advances in the

SUBMITTER: Li K 

PROVIDER: S-EPMC8497485 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature