Effects of leuprolide acetate on the quality of life of patients with prostate cancer: A prospective longitudinal cohort study.

ABSTRACT:

Purpose

The aim of this study was to investigate the effect of androgen deprivation therapy (ADT) on the health-related quality of life (HRQOL) of patients with prostate cancer (PC) and compare the changes in the HRQOL between ADT alone and ADT plus intensity-modulated radiation therapy (IMRT).

Materials and methods

Patients with PC were prospectively recruited between October 2018 and April 2020. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and the PC-specific module (PR25) were administered before ADT (baseline) and at 3, 6, and 12 months after ADT. All patients received subcutaneous injections of 45 mg leuprolide acetate at 6-month intervals for 12 months.

Results

Fifty-five of the 71 patients (77.5%) completed the 12

SUBMITTER: Kim MS 

PROVIDER: S-EPMC8498686 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature