Dataset Information

Prime-Boost Vaccination With BNT162b2 Induces High Neutralizing Activity Against SARS-CoV-2 Variants in Naive and COVID-19-Convalescent Individuals.

ABSTRACT:

Background

The objective of this study was to investigate the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VoC) during coronavirus disease 2019 (COVID-19) convalescence and after vaccination.

Methods

COVID-19-convalescent and -naïve individuals were tested for neutralizing activity against SARS-CoV-2 VoC Alpha, Beta, Gamma, and Delta at 1 and 7 months postinfection and 4-6 weeks after BNT162b2 vaccination.

Results

Vaccination induced a high neutralizing response in naïve individuals. Interestingly, vaccination of convalescent patients induced a boosted response that was able to neutralize all VoC at high titers.

Conclusions

Vaccination with BNT162b2 induced high levels of neutralization against SARS-CoV-2 VoC in most patients; this is especially beneficial in COVID-19-convalescent individuals.

SUBMITTER: Luczkowiak J

PROVIDER: S-EPMC8500154 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Prime-Boost Vaccination With BNT162b2 Induces High Neutralizing Activity Against SARS-CoV-2 Variants in Naïve and COVID-19-Convalescent Individuals.

Luczkowiak Joanna J Labiod Nuria N Rivas Gonzalo G Rolo Marta M Lasala Fátima F Lora-Tamayo Jaime J Mancheno-Losa Mikel M Rial David D Pérez-Rivilla Alfredo A Folgueira María D MD Delgado Rafael R

Open forum infectious diseases 20210924 10

<h4>Background</h4>The objective of this study was to investigate the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VoC) during coronavirus disease 2019 (COVID-19) convalescence and after vaccination.<h4>Methods</h4>COVID-19-convalescent and -naïve individuals were tested for neutralizing activity against SARS-CoV-2 VoC Alpha, Beta, Gamma, and Delta at 1 and 7 months postinfection and 4-6 weeks after BNT162b2 vaccination.<h4>Resul ...[more]

PMID: 34642637

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