Anthrahydroquinone-2-6-disulfonate is a novel, powerful antidote for paraquat poisoning.

ABSTRACT: Paraquat (PQ) is a widely used fast-acting pyridine herbicide. Accidental ingestion or self-administration via various routes can cause severe organ damage. Currently, no effective antidote is available commercially, and the mortality rate of poisoned patients is exceptionally high. Here, the efficacy of anthrahydroquinone-2-6-disulfonate (AH₂QDS) was observed in treating PQ poisoning by constructing in vivo and ex vivo models. We then explored the detoxification mechanism of AH₂QDS. We demonstrated that, in a rat model, the PQ concentration in the PQ + AH₂QDS group significantly decreased compared to the PQ only group. Additionally, AH₂QDS protected the mitochondria of rats and A549 cells and decreased oxidative stress damage, thus improving ani

SUBMITTER: Qian J 

PROVIDER: S-EPMC8505516 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature