Comparing second cancer risk for multiple radiotherapy modalities in survivors of hodgkin lymphoma.

ABSTRACT:

Objectives

To assess if excess absolute risk (EAR) of radiation-induced solid cancer can be used to rank radiotherapy plans for treatment of Hodgkin lymphoma (HL) in a statistically significant way.

Methods

EAR models, calibrated with data from the Life Span Study and HL survivors, have been incorporated into a voxelised risk-calculation software, which is used to compare four treatment modalities planned for five virtual HL patients. Organ-specific parameters are generated repeatedly in a Monte Carlo fashion to model their uncertainties. This in turn enables a quantitative estimation of the EAR uncertainties.

Results

Parameter-driven uncertainties on total EAR are around 13%, decreasing to around 2-5% for relative EAR comparisons. Total EAR estimations indicate that

SUBMITTER: Timlin C 

PROVIDER: S-EPMC8506169 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature