Dataset Information

Histology of Tooth Development in 3D Animation Video and Images - A Preliminary Report.

ABSTRACT: The process of tooth development is both, fascinating and well-described aspect of embryology. Although a big deal of the dental literature is being focused to the understanding of early stages of tooth development, still huge gap exist in our knowledge on how the dental hard tissues are formed, based on available images and descriptions. Tooth development process takes place in 3D form, inside our body. Therefore, histology should also be additionally explained with the help of additional 3D images and a video, which have not been reported so far. Methodology: Therefore, this brief article is a technical note and preliminary attempt to showcase 3D animation images and video of stages of tooth development which have been designed by the author herself using various the 3D animation softwares such as 3D max (Autodesk Media and Entertainment, San Rafael, California) and Adobe Premiere Pro 5.5 software which is a video-editing software (Adobe Systems, San Rafael, California).

SUBMITTER: Tamgadge S

PROVIDER: S-EPMC8507514 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature

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Histology of Tooth Development in 3D Animation Video and Images - A Preliminary Report.

Tamgadge Sandhya S Tamgadge Avinash A

Journal of microscopy and ultrastructure 20201109 3

The process of tooth development is both, fascinating and well-described aspect of embryology. Although a big deal of the dental literature is being focused to the understanding of early stages of tooth development, still huge gap exist in our knowledge on how the dental hard tissues are formed, based on available images and descriptions. Tooth development process takes place in 3D form, inside our body. Therefore, histology should also be additionally explained with the help of additional 3D im ...[more]

PMID: 34729356

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Project description:Trichuriasis, a well-known type of soil-transmitted helminthiasis, is a neglected gastrointestinal nematode disease predominantly affecting children in tropical regions and is caused by Trichuris trichiura. The potential zoonotic transmission of this disease is indicated by its presence in nonhuman primates. Chronic infection leads to mucosal damage, bacterial translocation, and intense inflammatory infiltration; however, the progression of these processes remains poorly understood. This study tracks the acute phase of experimental trichuriasis, providing detailed insights into nematode tissue migration stages, inflammatory infiltration, cytokine production, and 2D/3D imaging of the bacterial translocation process. We showed a mixed immune response (Th1, Th2, and Th17) initiated by larval-induced lesions in the intestine tissue and modulated by L4 larvae and adult worms in the cecum, with systemic changes observed in the mesenteric lymph nodes, peritoneal macrophages, and spleen. Despite the disruption of the intestinal mucosa within the first 10 days post-infection (d.p.i.), bacterial invasion becomes evident only after the development of the nematode into the L3 larval stage (17 d.p.i.), intensifying with lesions caused by the L4 larvae (22 d.p.i.) and adult worms (35 d.p.i.). Our multidimensional approach, which incorporates microscopy tools, micro-CT, physiological evaluations, tissue/organ assessments, and immunological parameters, demonstrates the ability of larvae to breach the intestinal mucosa, further indicating the timing of extensive bacterial infiltration. Additionally, a 3D animation illustrates how adult worm attachment mechanisms may facilitate bacterial translocation. This study provides significant insights into the immunological and pathological mechanisms of trichuriasis progression, highlighting the complex interplay among host immune responses, the gut microbiome, and parasite survival strategies, all of which are crucial aspects for future therapeutic development.

Dataset Information

Histology of Tooth Development in 3D Animation Video and Images - A Preliminary Report.

Publications

Histology of Tooth Development in 3D Animation Video and Images - A Preliminary Report.

Similar Datasets

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