Possible Roles of Calreticulin in Uterine Decidualization and Receptivity in Rats and Humans.

ABSTRACT: Previous in vitro studies have suggested that calreticulin (CALR), which is responsible for the folding and quality control of glycoproteins, may be associated with decidualization. However, its precise role in regulating decidualization has not been explored in vivo. Here, we used pregnant rat models to examine endometrial CALR expression during the peri-implantation period. We also examined whether polypectomy, a procedure that could ameliorate infertility, alters the endometrial expression levels of CALR and several implantation factors in women diagnosed as infertile. In rats, uterine CALR was expressed at a high level at the implantation site, and a marked increase in CALR expression was observed in decidual cells of normal pregnancy. In addition, endometrial CALR expression was enhan

SUBMITTER: Yoshie M 

PROVIDER: S-EPMC8509037 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature