Genome-wide analysis of DNA methylation in 106 schizophrenia family trios in Han Chinese.

ABSTRACT:

Background

Schizophrenia (SCZ) is a severe psychiatric disorder that affects approximately 0.75% of the global population. Both genetic and environmental factors contribute to development of SCZ. SCZ tends to run in family while both genetic and environmental factor contribute to its etiology. Much evidence suggested that alterations in DNA methylations occurred in SCZ patients.

Methods

To investigate potential inheritable pattern of DNA methylation in SCZ family, we performed a genome-wide analysis of DNA methylation of peripheral blood samples from 106 Chinese SCZ family trios. Genome-wide DNA methylations were quantified by Agilent 1 × 244 k Human Methylation Microarray.

Findings

In this study, we proposed a loci inheritance frequency model that allows characteriza

SUBMITTER: Shen L 

PROVIDER: S-EPMC8511801 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature