Reduced white matter microstructure in bipolar disorder with and without psychosis.

ABSTRACT:

Objectives

Affective and psychotic features overlap considerably in bipolar I disorder, complicating efforts to determine its etiology and develop targeted treatments. In order to clarify whether mechanisms are similar or divergent for bipolar disorder with psychosis (BDP) and bipolar disorder with no psychosis (BDNP), neurobiological profiles for both the groups must first be established. This study examines white matter structure in the BDP and BDNP groups, in an effort to identify portions of white matter that may differ between the bipolar and healthy groups or between the bipolar subgroups themselves.

Methods

Diffusion-weighted imaging data were acquired from participants with BDP (n = 45), BDNP (n = 40), and healthy comparisons (HC) (n = 66). Fractional anisotropy (FA)

SUBMITTER: Brown JA 

PROVIDER: S-EPMC8514149 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature