Auditory discrimination and frequency modulation learning in schizophrenia patients: amphetamine within-subject dose response and time course.

ABSTRACT:

Background

Auditory frequency modulation learning ('auditory learning') is a key component of targeted cognitive training (TCT) for schizophrenia. TCT can be effective in enhancing neurocognition and function in schizophrenia, but such gains require significant time and effort and elude many patients.

Methods

As a strategy to increase and/or accelerate TCT-induced clinical gains, we tested the dose- and time-course effects of the pro-attentional drug, amphetamine (AMPH; placebo, 2.5, 5 or 10 mg po; within-subject double-blind, order balanced) on auditory learning in schizophrenia patients [n = 32; M:F = 19:13; age 42.0 years (24-55)]. To understand predictors and/or mechanisms of AMPH-enhanced TCT, we also measured auditory fidelity (words-in-noise (WIN), quick speech

SUBMITTER: Swerdlow NR 

PROVIDER: S-EPMC8514598 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature