Dataset Information

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.

ABSTRACT:

Aims

Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear.

Methods and results

Here, we show in humans and mice that leucocytes deplete rapidly from the blood after a single episode of acute mental stress. Using cell-tracking experiments in animal models of acute mental stress, we found that stress exposure leads to prompt uptake of inflammatory leucocytes from the blood to distinct tissues including heart, lung, skin, and, if present, atherosclerotic plaques. Mechanistically, we found that acute stress enhances leucocyte influx into mouse atherosclerotic plaques by modulating endothelial cells. Specifically, acute stress increases adhesion molecule expression and chemokine release through locally derived norepinephrine. Either chemical or surgical disruption of norepinephrine signalling diminished stress-induced leucocyte migration into mouse atherosclerotic plaques.

Conclusion

Our data show that acute mental stress rapidly amplifies inflammatory leucocyte expansion inside mouse atherosclerotic lesions and promotes plaque vulnerability.

SUBMITTER: Hinterdobler J

PROVIDER: S-EPMC8516477 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.

Hinterdobler Julia J Schott Simin S Jin Hong H Meesmann Almut A Steinsiek Anna-Lena AL Zimmermann Anna-Sophia AS Wobst Jana J Müller Philipp P Mauersberger Carina C Vilne Baiba B Baecklund Alexandra A Chen Chien-Sin CS Moggio Aldo A Braster Quinte Q Molitor Michael M Krane Markus M Kempf Wolfgang E WE Ladwig Karl-Heinz KH Hristov Michael M Hulsmans Maarten M Hilgendorf Ingo I Weber Christian C Wenzel Philip P Scheiermann Christoph C Maegdefessel Lars L Soehnlein Oliver O Libby Peter P Nahrendorf Matthias M Schunkert Heribert H Kessler Thorsten T Sager Hendrik B HB

European heart journal 20211001 39

<h4>Aims</h4>Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear.<h4>Methods and results</h4>Here, we show in humans and mice that leucocytes deplete rapidly from the blood after a single episode of acute mental stress. Using cell-tracking experiments in animal models of acute mental stress, we found that stress expo ...[more]

PMID: 34279021

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Dataset Information

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.

Aims

Methods and results

Conclusion

Publications

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.

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