Complementary Transcriptomic and Proteomic Analysis in the Substantia Nigra of Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is a disease that involves brain damage and is associated with neuroinflammation, mitochondrial damage, and cell aging. However, the pathogenic mechanism of PD is still unknown. Sequencing data and proteomic data can describe the fluctuation of molecular abundance in diseases at the mRNA level and protein level, respectively. In order to explore new targets in the pathogenesis of PD, the study analyzed molecular changes from the database by combining transcriptomic and proteomic analysis. Differentially expressed genes and differentially abundant proteins were summarized and analyzed. Enrichment and cluster analysis emphasized the importance of neurotransmitter release, mitochondrial damage, and vesicle transport. The molecular network revealed a subnetwork of 9 mo

SUBMITTER: Dong BH 

PROVIDER: S-EPMC8517625 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature