A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control.

ABSTRACT: We have analyzed the link between the gene regulation and growth during the early stages of flower development in Arabidopsis. Starting from time-lapse images, we generated a 4D atlas of early flower development, including cell lineage, cellular growth rates, and the expression patterns of regulatory genes. This information was introduced in MorphoNet, a web-based platform. Using computational models, we found that the literature-based molecular network only explained a minority of the gene expression patterns. This was substantially improved by adding regulatory hypotheses for individual genes. Correlating growth with the combinatorial expression of multiple regulators led to a set of hypotheses for the action of individual genes in morphogenesis. This identified the central factor LEAFY

SUBMITTER: Refahi Y 

PROVIDER: S-EPMC8519405 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature