Dataset Information

Effectiveness of hygiene kit distribution to reduce cholera transmission in Kasai-Oriental, Democratic Republic of Congo, 2018: a prospective cohort study.

ABSTRACT:

Introduction

Household contacts of cholera cases are at a greater risk of Vibrio cholerae infection than the general population. There is currently no agreed standard of care for household contacts, despite their high risk of infection, in cholera response strategies. In 2018, hygiene kit distribution and health promotion was recommended by Médecins Sans Frontières for admitted patients and accompanying household members on admission to a cholera treatment unit in the Democratic Republic of Congo.

Methods

To investigate the effectiveness of the intervention and risk factors for cholera infection, we conducted a prospective cohort study and followed household contacts for 7 days after patient admission. Clinical surveillance among household contacts was based on self-reported symptoms of cholera and diarrhoea, and environmental surveillance through the collection and analysis of food and water samples.

Results

From 94 eligible households, 469 household contacts were enrolled and 444 completed follow-up. Multivariate analysis suggested evidence of a dose-response relationship with increased kit use associated with decreased relative risk of suspected cholera: household contacts in the high kit-use group had a 66% lower incidence of suspected cholera (adjusted risk ratio (aRR) 0.34, 95% CI 0.11 to 1.03, p=0.055), the mid-use group had a 53% lower incidence (aRR 0.47, 95% CI 0.17 to 1.29, p=1.44) and low-use group had 22% lower incidence (aRR 0.78, 95% CI 0.24 to 2.53, p=0.684), compared with household contacts without a kit. Drinking water contamination was significantly reduced among households in receipt of a kit. There was no significant effect on self-reported diarrhoea or food contamination.

Conclusion

The integration of a hygiene kit intervention to case-households may be effective in reducing cholera transmission among household contacts and environmental contamination within the household. Further work is required to evaluate whether other proactive localised distribution among patients and case-households or to households surrounding cholera cases can be used in future cholera response programmes in emergency contexts.

SUBMITTER: D'Mello-Guyett L

PROVIDER: S-EPMC8522665 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Effectiveness of hygiene kit distribution to reduce cholera transmission in Kasaï-Oriental, Democratic Republic of Congo, 2018: a prospective cohort study.

D'Mello-Guyett Lauren L Cumming Oliver O Bonneville Sharla S D'hondt Rob R Mashako Maria M Nakoka Brunette B Gorski Alexandre A Verheyen Dorien D Van den Bergh Rafael R Welo Placide Okitayemba PO Maes Peter P Checchi Francesco F

BMJ open 20211014 10

<h4>Introduction</h4>Household contacts of cholera cases are at a greater risk of <i>Vibrio cholerae</i> infection than the general population. There is currently no agreed standard of care for household contacts, despite their high risk of infection, in cholera response strategies. In 2018, hygiene kit distribution and health promotion was recommended by Médecins Sans Frontières for admitted patients and accompanying household members on admission to a cholera treatment unit in the Democratic R ...[more]

PMID: 34649847

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