Cost-effectiveness of rapid laboratory-based mass-spectrometry diagnosis of bloodstream infection: evidence from the RAPIDO randomised controlled trial.

ABSTRACT:

Objectives and intervention

Bloodstream infection, the presence of viable micro-organisms in the blood, is a prevalent clinical event associated with substantial mortality. Patient outcomes may be improved when the causative micro-organism is identified quickly. We assessed the cost-effectiveness of rapid microbial identification by matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry.

Design

Economic evaluation alongside a randomised multicentre trial (RAPIDO: RAPId Diagnosis on Outcome) assessing the impact of rapid identification by MALDI-TOF spectrometry.

Setting

Adult inpatients with bloodstream infections at seven National Health Service hospital trusts in England and Wales.

Primary outcome

Net monetary benefit, estimat

SUBMITTER: Dixon P 

PROVIDER: S-EPMC8524273 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature