Model Based Identification of Linezolid Exposure-toxicity Thresholds in Hospitalized Patients.

ABSTRACT: Evidence supports linezolid therapeutic drug monitoring as the exposure-response relationship has been identified for toxicity among patients receiving linezolid, but the data to establish the upper limit are limited and the published toxicity thresholds range widely. The purpose of this study was to determine the linezolid exposure-toxicity thresholds to improve the safety of linezolid. This is a multicenter retrospective study of adult patients treated with linezolid from 2018 to 2019. The population pharmacokinetic model of linezolid was established based on 270 plasma concentrations in 152 patients, which showed creatinine clearance and white cell count are covariates affecting the clearance of linezolid, and serum albumin is the covariate affecting the volume of distribution. Classifi

SUBMITTER: Fang J 

PROVIDER: S-EPMC8525462 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature