[Expression characteristics and functional analysis of ELK3 in gastric cancer].

ABSTRACT:

Objective

To explore the expression characteristics of ELK3 and its role in the occurrence, progression and prognosis of gastric cancer.

Methods

We analyzed the expression characteristics of ELK3 in gastric cancer based on E-MTAB-6693 dataset and explored the prognostic value of ELK3 using Kaplan-Meier survival analysis and univariate and multivariate Cox regression analysis. Chip-Atlas, ChipBase, Genes Transcription Regulation Database, and hTFtarget were used for predicting the target genes of ELK3 and constructing the transcription regulation network. Functional enrichment analysis of the target genes was performed using R software. The proportions of infiltrating immune cells in gastric cancer were analyzed using Cibersort tool, and the Pearson coefficients between ELK3

SUBMITTER: Zhou L 

PROVIDER: S-EPMC8526318 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature