Increased intracellular Cl^- concentration in pulmonary arterial myocytes is associated with chronic hypoxic pulmonary hypertension.

ABSTRACT: Chloride channels play an important role in regulating smooth muscle contraction and proliferation, and contribute to the enhanced constriction of pulmonary arteries (PAs) in pulmonary hypertension (PH). The intracellular Cl^- concentration ([Cl^-]_i), tightly regulated by various Cl^- transporters, determines the driving force for Cl^- conductance, thereby the functional outcome of Cl^- channel activation. This study characterizes for the first time the expression profile of Cl^- transporters/exchangers in PA smooth muscle and provides the first evidence that the intracellular Cl^- homeostasis is altered in PA smooth muscle cells (PASMCs) associated with chronic hypoxic PH (CHPH). Quantitative RT-PCR revealed

SUBMITTER: Sun H 

PROVIDER: S-EPMC8526344 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature