The impact of an URAT1 polymorphism on the losartan treatment of hypertension and hyperuricemia.

ABSTRACT:

Background

This study was designed to evaluate the impact of polymorphisms in the urate transporter 1 (URAT1) gene on the uricosuric action of losartan therapy in hypertensive patients suffering from hyperuricemia.

Methods

A MassARRAY approach was used to detect single nucleotide polymorphism (SNP) loci in the URAT1 and CYP2C9 genes (16 and 2 loci, respectively) in 111 patients with hypertension and hyperuricemia taking losartan and in 121 healthy controls. In addition, we compared serum urate (SUA) levels and other key clinical biochemistry indices between these two patient groups.

Results

We detected significant differences between the two patient groups with respect to age, SUA, urea, creatine, triglycerides, high-density lipoprotein, low-density lipoprotein, and f

SUBMITTER: Wu L 

PROVIDER: S-EPMC8529133 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature