Modeling the Heterodimer Interfaces of Melatonin Receptors.

ABSTRACT: Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland. Melatonin is a key regulator in the control of circadian rhythm and has multiple functional roles in retinal physiology, memory, immunomodulation and tumorigenesis. The two subtypes of human melatonin receptors, termed MT₁ and MT₂, utilize overlapping signaling pathways although biased signaling properties have been reported in some cellular systems. With the emerging concept of GPCR dimerization, melatonin receptor heterodimers have been proposed to participate in system-biased signaling. Here, we used computational approaches to map the dimerization interfaces of known heter

SUBMITTER: Tse LH 

PROVIDER: S-EPMC8529217 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature