Prophylactic Topical Antibiotics in Fracture Repair and Spinal Fusion.

ABSTRACT:

Introduction

The objective of this systematic review with meta-analysis is to determine whether prophylactic local antibiotics prevent surgical site infections (SSIs) in instrumented spinal fusions and traumatic fracture repair. A secondary objective is to investigate the effect of vancomycin, a common local antibiotic of choice, on the microbiology of SSIs.

Methods

An electronic search of PubMed, EMBASE, and Web of Science databases and major orthopedic surgery conferences was conducted to identify studies that (1) were instrumented spinal fusions or fracture repair and (2) had a treatment group that received prophylactic local antibiotics. Both randomized controlled trials (RCTs) and comparative observational studies were included. Meta-analysis was performed separately fo

SUBMITTER: Kim EK 

PROVIDER: S-EPMC8531801 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature