The performance of common SNP arrays in assigning African mitochondrial haplogroups.

ABSTRACT:

Background

Mitochondrial haplogroup assignment is an important tool for forensics and evolutionary genetics. African populations are known to display a high diversity of mitochondrial haplogroups. In this research we explored mitochondrial haplogroup assignment in African populations using commonly used genome-wide SNP arrays.

Results

We show that, from eight commonly used SNP arrays, two SNP arrays outperform the other arrays when it comes to the correct assignment of African mitochondrial haplogroups. One array enables the recognition of 81% of the African mitochondrial haplogroups from our compiled dataset of full mitochondrial sequences. Other SNP arrays were able to assign 4-62% of the African mitochondrial haplogroups present in our dataset. We also assessed the perfor

SUBMITTER: Lankheet I 

PROVIDER: S-EPMC8532338 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature