Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System.

ABSTRACT:

Background

Porous polyethylene (PPE) implants are used for the reconstruction of tissue defects but have a risk of rejection in case of insufficient ingrowth into the host tissue. Various growth factors can promote implant ingrowth, yet a long-term gradient is a prerequisite for the mediation of these effects. As modification of the implant surface with nanocarriers may facilitate a long-term gradient by sustained factor release, implants modified with crosslinked albumin nanocarriers were evaluated in vivo.

Methods

Nanocarriers from murine serum albumin (MSA) were prepared by an inverse miniemulsion technique encapsulating either a low- or high-molar mass fluorescent cargo. PPE implants were subsequently coated with these nanocarriers. In control cohorts, the implant was co

SUBMITTER: Eckrich J 

PROVIDER: S-EPMC8533240 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature