Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine.
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ABSTRACT:
SUBMITTER: Barry ER
PROVIDER: S-EPMC8534579 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine.
Barry Evan R ER Simov Vladimir V Valtingojer Iris I Venier Olivier O
Cells 20211011 10
The Hippo pathway is an evolutionary conserved signaling network that regulates essential processes such as organ size, cell proliferation, migration, stemness and apoptosis. Alterations in this pathway are commonly found in solid tumors and can lead to hyperproliferation, resistance to chemotherapy, compensation for mKRAS and tumor immune evasion. As the terminal effectors of the Hippo pathway, the transcriptional coactivators YAP1/TAZ and the transcription factors TEAD1-4 present exciting oppo ...[more]
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