Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria.

ABSTRACT: Pathogenic drug-resistant bacteria represent a threat to human health, for instance, the methicillin-resistant Staphylococcus aureus (MRSA). There is an ever-growing need to develop non-antibiotic strategies to fight bacteria without triggering drug resistance. Here, we design a hedgehog artificial macrophage with atomic-catalytic centers to combat MRSA by mimicking the "capture and killing" process of macrophages. The experimental studies and theoretical calculations reveal that the synthesized materials can efficiently capture and kill MRSA by the hedgehog topography and substantial generation of •O₂^- and HClO with its Fe₂N₆O catalytic centers. The synthesized artificial macrophage exhibits a low minimal inhibition concentration (8 μg/mL Fe-Art

SUBMITTER: Long Y 

PROVIDER: S-EPMC8536674 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature