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Intracellular Behaviour of Legionella Non-pneumophila Strains within Three Amoeba Strains, Including Willaertia magna C2c Maky.


ABSTRACT: Legionellosis, an often-lethal pneumonia, is generally associated with contamination by Legionella pneumophila. This bacterium can persist in the environment and resist chemical treatment when it is internalized by amoebae. In addition, there is increasing medical proof that other Legionella species can be causative agents of Legionellosis. The objective of this study was to evaluate whether Legionella non-pneumophila (Lnp) strains were able to use the machinery of amoeba to multiply, or whether amoebae were able to limit their proliferation. Seven strains belonging to the species L. longbeachae, L. anisa, L. bozemanae, L. taurinensis, and L. dumoffii were cocultured with three amoebae, Acanthamoeba castellanii, Willaertia magna T5(S)44, and Willaertia magna C2c Maky, at two temperatures, 22 and 37 °C. We found that at 22 °C, all amoebae were able to phagocytose the seven Lnp strains and to avoid intracellular development, except for L. longbeachae, which was able to multiply inside W. magna T5(S)44. At 37 °C, four Lnp strains were able to hijack the machinery of one or two amoebae and to use it to proliferate, but none were able to multiply inside W. magna C2c Maky.

SUBMITTER: Croze A 

PROVIDER: S-EPMC8538512 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Intracellular Behaviour of <i>Legionella</i> Non-<i>pneumophila</i> Strains within Three Amoeba Strains, Including <i>Willaertia magna</i> C2c Maky.

Croze Aurélien A   Carlino Antoine A   Quélard Benjamin B   Saha Adeline A   Convert Tiphaine T   Eberst Jean-Baptiste JB   Demanèche Sandrine S  

Pathogens (Basel, Switzerland) 20211019 10


Legionellosis, an often-lethal pneumonia, is generally associated with contamination by <i>Legionella pneumophila</i>. This bacterium can persist in the environment and resist chemical treatment when it is internalized by amoebae. In addition, there is increasing medical proof that other <i>Legionella</i> species can be causative agents of Legionellosis. The objective of this study was to evaluate whether <i>Legionella</i> non-<i>pneumophila</i> (Lnp) strains were able to use the machinery of am  ...[more]

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