Ontology highlight
ABSTRACT:
SUBMITTER: Antoniadou K
PROVIDER: S-EPMC8540557 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Antoniadou Kyriaki K Herz Corinna C Le Nguyen Phan Khoi NPK Mittermeier-Kleßinger Verena Karolin VK Förster Nadja N Zander Matthias M Ulrichs Christian C Mewis Inga I Hofmann Thomas T Dawid Corinna C Lamy Evelyn E
International journal of molecular sciences 20211015 20
<i>Salix</i> cortex-containing medicine is used against pain conditions, fever, headaches, and inflammation, which are partly mediated via arachidonic acid-derived prostaglandins (PGs). We used an activity-guided fractionation strategy, followed by structure elucidation experiments using LC-MS/MS, CD-spectroscopy, and 1D/2D NMR techniques, to identify the compounds relevant for the inhibition of PGE<sub>2</sub> release from activated human peripheral blood mononuclear cells. Subsequent compound ...[more]