Genome-Wide Association Study of Peripheral Artery Disease.

ABSTRACT:

Background

Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with PAD overall and in the contexts of diabetes and smoking status.

Methods

We identified genetic variants associated with PAD and then meta-analyzed with published summary statistics from the Million Veterans Program and UK Biobank to replicate their findings. Next, we ran stratified genome-wide association analysis in ever smokers, never smokers, individuals with diabetes, and individuals with no history of diabetes and corresponding interaction analyses, to identify variants that modify the risk of PAD by diabetic or smoking status.

Results

We identified 5 genome-wide significant (

SUBMITTER: van Zuydam NR 

PROVIDER: S-EPMC8542067 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature