hGATA1 Under the Control of a μLCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the Gata1 ^low Mutation in Mice.

ABSTRACT: The phenotype of mice carrying the Gata1 ^low mutation that decreases expression of Gata1 in erythroid cells and megakaryocytes, includes anemia, thrombocytopenia, hematopoietic failure in bone marrow and development of extramedullary hematopoiesis in spleen. With age, these mice develop myelofibrosis, a disease sustained by alterations in stem/progenitor cells and megakaryocytes. This study analyzed the capacity of hGATA1 driven by a μLCR/β-globin promoter to rescue the phenotype induced by the Gata1 ^low mutation in mice. Double hGATA1/Gata1 ^low/0 mice were viable at birth with hematocrits greater than those of their Gata1 ^low/0 littermates but platelet cou

SUBMITTER: Martelli F 

PROVIDER: S-EPMC8542976 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature