Dataset Information

The Value of ¹⁸F-FDG PET/CT in Evaluating Disease Severity and Prognosis in Idiopathic Pulmonary Fibrosis Patients.

ABSTRACT:

Background

Several parameters are useful for assessing disease severity in idiopathic pulmonary fibrosis (IPF); however, the role of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) is not well-defined. We aimed to evaluate the value of ¹⁸F-FDG PET/CT for assessing disease severity and prognosis in IPF patients.

Methods

Clinical data of 89 IPF patients (mean age: 68.1 years, male: 94%) who underwent ¹⁸F-FDG PET/CT for evaluation of lung nodules or cancer staging were retrospectively reviewed. Mean and maximal standardized uptake values (SUV_mean, SUV_max, respectively) were measured in the fibrotic area. Adjusted SUV, including SUV ratio (SUVR, defined as SUV_max-to-liver SUV_mean ratio), tissue fraction-corrected SUV_mean (SUV_meanTF), and SUVR (SUVR_TF), and tissue-to-blood ratio (SUV_max/SUV_mean venous; TBR_blood) were obtained. Death was defined as the primary outcome, and associations between other clinical parameters (lung function, exercise capacity, C-reactive protein [CRP] level) were also investigated.

Results

All SUV parameters were inversely correlated with the forced vital capacity, diffusing capacity for carbon monoxide, and positively correlated with CRP level and the gender-age-physiology index. The SUV_mean, SUV_max, and SUV_meanTF were associated with changes in lung function at six months. The SUVR (hazard ratio [HR], 1.738; 95% confidence interval [CI], 1.011-2.991), SUVR_TF (HR, 1.441; 95% CI, 1.000-2.098), and TBR_blood (HR, 1.377; 95% CI, 1.038-1.827) were significant predictors for mortality in patients with IPF in the univariate analysis, but not in the multivariate analysis.

Conclusion

¹⁸F-FDG PET/CT may provide additional information on the disease severity and prognosis in IPF patients, and the SUVR may be superior to other SUV parameters.

SUBMITTER: Yoon HY

PROVIDER: S-EPMC8546311 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

The Value of <sup>18</sup>F-FDG PET/CT in Evaluating Disease Severity and Prognosis in Idiopathic Pulmonary Fibrosis Patients.

Yoon Hee-Young HY Lee Suk Hyun SH Ha Sejin S Ryu Jin-Sook JS Song Jin Woo JW

Journal of Korean medical science 20211025 41

<h4>Background</h4>Several parameters are useful for assessing disease severity in idiopathic pulmonary fibrosis (IPF); however, the role of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) is not well-defined. We aimed to evaluate the value of <sup>18</sup>F-FDG PET/CT for assessing disease severity and prognosis in IPF patients.<h4>Methods</h4>Clinical data of 89 IPF patients (mean age: 68.1 years, male: 94%) who underwent <sup>18</ ...[more]

PMID: 34697928

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Dataset Information

The Value of ¹⁸F-FDG PET/CT in Evaluating Disease Severity and Prognosis in Idiopathic Pulmonary Fibrosis Patients.

Background

Methods

Results

Conclusion

Publications

The Value of <sup>18</sup>F-FDG PET/CT in Evaluating Disease Severity and Prognosis in Idiopathic Pulmonary Fibrosis Patients.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The Value of 18F-FDG PET/CT in Evaluating Disease Severity and Prognosis in Idiopathic Pulmonary Fibrosis Patients.

Background

Methods

Results

Conclusion

Publications

The Value of <sup>18</sup>F-FDG PET/CT in Evaluating Disease Severity and Prognosis in Idiopathic Pulmonary Fibrosis Patients.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

The Value of ¹⁸F-FDG PET/CT in Evaluating Disease Severity and Prognosis in Idiopathic Pulmonary Fibrosis Patients.