Dataset Information

Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.

ABSTRACT:

Aims

The risk of antipsychotic-associated cardiovascular and metabolic events may differ among countries, and limited real-world evidence has been available comparing the corresponding risks among children and young adults. We, therefore, evaluated the risks of cardiovascular and metabolic events in children and young adults receiving antipsychotics.

Methods

We conducted a multinational self-controlled case series (SCCS) study and included patients aged 6-30 years old who had both exposure to antipsychotics and study outcomes from four nationwide databases of Taiwan (2004-2012), Korea (2010-2016), Hong Kong (2001-2014) and the UK (1997-2016) that covers a total of approximately 100 million individuals. We investigated three antipsychotics exposure windows (i.e., 90 days pre-exposure, 1-30 days, 30-90 days and 90 + days of exposure). The outcomes were cardiovascular events (stroke, ischaemic heart disease and acute myocardial infarction), or metabolic events (hypertension, type 2 diabetes mellitus and dyslipidaemia).

Results

We included a total of 48 515 individuals in the SCCS analysis. We found an increased risk of metabolic events only in the risk window with more than 90-day exposure, with a pooled IRR of 1.29 (95% CI 1.20-1.38). The pooled IRR was 0.98 (0.90-1.06) for 1-30 days and 0.88 (0.76-1.02) for 31-90 days. We found no association in any exposure window for cardiovascular events. The pooled IRR was 1.86 (0.74-4.64) for 1-30 days, 1.35 (0.74-2.47) for 31-90 days and 1.29 (0.98-1.70) for 90 + days.

Conclusions

Long-term exposure to antipsychotics was associated with an increased risk of metabolic events but did not trigger cardiovascular events in children and young adults.

SUBMITTER: Man KKC

PROVIDER: S-EPMC8546502 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.

Man Kenneth K C KKC Shao Shih-Chieh SC Chang Yu-Chuan YC Chi Mei-Hung MH Jeong Han Eol HE Lin Swu-Jane SJ Su Chien-Chou CC Shin Ju-Young JY Wong Kirstie H KH Wong Ian C K ICK Kao Yang Yea-Huei YH Yang Yen-Kuang YK Lai Edward Chia-Cheng EC

Epidemiology and psychiatric sciences 20211015

<h4>Aims</h4>The risk of antipsychotic-associated cardiovascular and metabolic events may differ among countries, and limited real-world evidence has been available comparing the corresponding risks among children and young adults. We, therefore, evaluated the risks of cardiovascular and metabolic events in children and young adults receiving antipsychotics.<h4>Methods</h4>We conducted a multinational self-controlled case series (SCCS) study and included patients aged 6-30 years old who had both ...[more]

PMID: 34751642

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Dataset Information

Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.

Aims

Methods

Results

Conclusions

Publications

Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.

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