Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.

ABSTRACT:

Aims

The risk of antipsychotic-associated cardiovascular and metabolic events may differ among countries, and limited real-world evidence has been available comparing the corresponding risks among children and young adults. We, therefore, evaluated the risks of cardiovascular and metabolic events in children and young adults receiving antipsychotics.

Methods

We conducted a multinational self-controlled case series (SCCS) study and included patients aged 6-30 years old who had both exposure to antipsychotics and study outcomes from four nationwide databases of Taiwan (2004-2012), Korea (2010-2016), Hong Kong (2001-2014) and the UK (1997-2016) that covers a total of approximately 100 million individuals. We investigated three antipsychotics exposure windows (i.e., 90 days pre-

SUBMITTER: Man KKC 

PROVIDER: S-EPMC8546502 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature