Advanced image-supported lead placement in cardiac resynchronisation therapy: protocol for the multicentre, randomised controlled ADVISE trial and early economic evaluation.

ABSTRACT:

Introduction

Achieving optimal placement of the left ventricular (LV) lead in cardiac resynchronisation therapy (CRT) is a prerequisite in order to achieve maximum clinical benefit, and is likely to help avoid non-response. Pacing outside scar tissue and targeting late activated segments may improve outcome. The present study will be the first randomised controlled trial to compare the efficacy of real-time image-guided LV lead delivery to conventional CRT implantation. In addition, to estimate the cost-effectiveness of targeted lead implantation, an early decision analytic model was developed, and described here.

Methods and analysis

A multicentre, interventional, randomised, controlled trial will be conducted in a total of 130 patients with a class I or IIa indicati

SUBMITTER: Wouters PC 

PROVIDER: S-EPMC8547507 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature