Intracranial Hemorrhage and 2-Year Neurodevelopmental Outcomes in Infants Born Extremely Preterm.

ABSTRACT:

Objectives

To determine the incidence, timing, progression, and risk factors for intracranial hemorrhage (ICH) in infants 24^0/7 to 27^6/7 weeks of gestational age and to characterize the association between ICH and death or neurodevelopmental impairment (NDI) at 2 years of corrected age.

Study design

Infants enrolled in the Preterm Erythropoietin Neuroprotection Trial had serial cranial ultrasound scans performed on day 1, day 7-9, and 36 weeks of postmenstrual age to evaluate ICH. Potential risk factors for development of ICH were examined. Outcomes included death or severe NDI as well as Bayley Scales of Infant and Toddler Development, 3rd Edition, at 2 years of corrected age.

Results

ICH was identified in 38% (n = 339) of 883 enrolled infants.

SUBMITTER: Law JB 

PROVIDER: S-EPMC8551011 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature